Hard sear the ground beef in a large skillet over medium-high heat, breaking it up as it browns.
While the beef cooks, season it with the kosher salt, black pepper, garlic powder, and onion powder.
Once the beef is about halfway cooked through, add the onion, celery, vegetable medley, frozen mixed vegetables, butter, Worcestershire sauce, minced garlic, Slap Ya Mama, and thyme.
Saute everything together until the vegetables are heated through and crisp-tender and the beef is fully cooked.
Serve on its own with hot sauce or BBQ sauce, or spoon over rice with your favorite sauce.